Hepbest 25 MG

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48.00 USD
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Drug profile for HepBest tablet

HepBest tablets are primarily used in hepatitis infection condition, is in chronic stage.

HepBest tablets are only used by the patients who are having a valid prescription

HepBest tablets are containing an anti-viral agent known as Tenofovir Alafenamide which may not cure the infection but may suppress the growth of virus.


Trade name: HepBest

Active component: Tenofovir Alafenamide

Strength: 25mg

Mfg: Natco

Pack: 30 tablets in a container

Category: Anti-hepaciviral activity


Prescribing information of HepBest

The most frequently used anti-viral agent like Tenofovir Alafenamide is primarily indicated for the treatment of chronic hepatitis B viral infection occurred in adults patient with compensated liver damage.


Mechanism of HepBest

HepBest worked in the body by some component incorporates;

For the most part HepBest containing tenofovir Alafenamide is a prodrug which is changed over into dynamic frame in-vivo

Tenofovir Alafenamide has cell penetrability property which is lipophilic in nature, infiltrates into hepatocytes by latent dissemination strategy and additionally by hepatic return transporters OATP1B1 and OATP1B3

In-vivo, tenofovir Alafenamide is changed into tenofovir a parent compound by experiencing hydrolysis with the chemical carboxylesterase 1 which is happen in hepatocytes cell

This dynamic frame tenofovir is phosphorylated into tenofovir diphosphate by cell kinase compounds

TAF has pharmacologically dynamic compound known as tenofovir diphosphate which is in charge of viral multiplication denial by means of imbuing into infection DNA with the assistance of turnaround transcriptase chemical which causes viral DNA chain end



Maximum plasma concentration time of TAF 0.48 hours



TAF is largely bound to human plasma protein at 80%

Protein binding data occurs in vivo

The blood plasma ratio of TAF is 1.0



The metabolism of TAF occurs with the help of;

Carboxyl esterase 1

Cathepsin A




Nearly 80% of TAF get metabolized and reaches its half life at 0.51 hour

<1% of metabolite released through urine

31.7% excreted via feces


When to take the HepBest tablets

HepBest tablets should be taken with food


Dosage regimens of HepBest

Before initiate the treatment with HepBest tablets, patients must be investigate whether they are suspected with HIV 1 infection or not.

The suggested dosage of HepBest is 25mg should be administered as a single dose.

In both mild to moderate liver and kidney impaired patients, dosage adjustment should not be allowed; whereas severe conditions, HepBest not recommended.


HepBest caused side effects

The most serious adverse effects;

Serious exacerbation of hepatitis B infection

Out breaking or worsening of renal damage

Lactic acidosis

Hepatomegaly with steatosis

Common side effects;




Back pain


Abdominal pain

Loss of bone mineral density


Increase in lipase & amylase

Increasing in serum lipids


Drug- drug interaction of HepBest

HepBest tablets with P-gp or BCRP inhibiting drugs, causes variation in absorption of TAF; this may leads to adverse effects.

HepBest tablets with P gp or BCRP inducing drugs causes depletion of absorption of TAF leads to increasing the concentration of TAF

HepBest tablets with renal function reducing drugs may leads to increasing the concentration and causes serious adverse effects

HepBest tablet combined with anti-convulsants leads to decreasing the effect of concentration of TAF

HepBest tablet combined with anti-mycobacterials causes reducing the effect of concentration of TAF

HepBest tablets concomitant use of herbal product like st, John’s wort, causes decreasing the TAF concentration.


Food drug interaction of HepBest;

Minor food drug interaction may occur; alcohol containing food items should not be suggested.

Consult with physician about the dietary.


Possible contraindications of HepBest

No specific contraindication occurs, if some patients may contraindicate to TAF causes anaphylactic reactions.


Safety measures

Aggravation of hepatitis B infection: Check the patient history before starting the treatment

Exposure of advancement of HIV-1 resistance: Due to this condition, HepBest tablets are not suggested for HIV-1 infections

New commencement of renal damage: To avoid concomitant use of HepBest with renal function depleting drugs

Lactic acidosis or hepatomegaly with steatosis: Stop the therapy with HepBest


Pregnancy and lactation

HepBest tablets are probably used in pregnancy conditions, only after knowing the risk of the product associated to fetus.

Breast feeding should not be suggested.


Storage and handling

HepBest tablet container should be kept at below 30oC

Protect the container from heat, moisture & heat


Missed dose

In case of missed dose, get advice from medical practitioner and their instruction; otherwise avoid the missed dose and follow the regular schedule.


Over dosage

If over dosage occurs during the therapy;

Provide the patients with supportive measures

Monitor the signs & symptoms

Hemodialysis is done, to eliminate the TAF content with the range of 54%.



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